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Central administration of palmitoylethanolamide cuts down hyperalgesia in mice via inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J Pharmacol1996). Oral PEA also minimized paw oedema induced by carrageenan, dextran and formalin, suggesting which the compound right down‐modulates mast mobile activation in vivo2007) and that